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sle systemic erythematosus differential management comparison signs symptoms msk pain approach classification druginduced gout rheumatoid testing treatment autoantibodies cppd criteria
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Pain - Diagnostic ... spondyloarthropathies, lupus ... #rheumatology # ... approach #workup ... #differential #diagnosis
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint ... B19 infection Malar ... lesions • Discoid lupus ... #differential #diagnosis ... #rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
M DAMN SHARP - Lupus ... Diagnosis Mnemonic ... Anti-phospholipid) M Malar ... cytopenias) A Arthritis ... erythematosus #rheumatology
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
Rheumatoid Arthritis ... of hands/feet, knees ... : CLINICAL DIAGNOSIS ... #Rheumatoid #Arthritis ... #rheumatology
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
• Inflammatory arthritis ... #Pain #MSK #rheumatology ... #approach #workup ... #differential #diagnosis ... #arthritis
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
with temporal arteritis ... Anti-retrovirals, Gemcitabine Lupus ... uncommon 5-15% of lupus ... #differential #diagnosis ... #comparison #rheumatology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Inflammatory Joint ... in Rheumatoid arthritis ... , Lupus, etc) -> ... commonly affects the knee ... JointDisease #JointPain #Diagnosis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Criteria for Systemic Lupus ... • Arthritis domain ... in at least 2 joints ... Erythematosus #diagnosis ... #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... of hip (rare), Arthritis ... in small joints ... signs #symptoms #diagnosis ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... & NPSLE rare, Malar ... • Immunologic Workup ... comparison #table #rheumatology ... #diagnosis #management
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