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differential erythematosus sle systemic vasculitis ana antinuclear classification management antibodies algorithm anemia autoantibodies comparison dermatology extravascular hemolysis hemolytic intravascular medications
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... cases, drug-dependent ... Lupusreference #druginduced ... #table #rheumatology ... #diagnosis #management
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... Anti-histone (in drug-induced ... seen in 30—70% of cases ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
M DAMN SHARP - Lupus ... Anti-phospholipid) M Malar ... Antinuclear Antibody (ANA ... Pleuritis) H Hematologic ... erythematosus #rheumatology
Drug-Induced Thrombocytopenia The diagnosis of drug-induced thrombocytopenia can be made only by demonstrating resolution of thrombocytopenia once
The diagnosis of ... are initially diagnosed ... #Diagnosis #Hematology ... #Differential #DrugInduced ... #Medications #Causes
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 Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... (C-ANCA): GPA > ... #differential #diagnosis ... #algorithm #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... disease (MCTD), Drug-induced ... Antinuclear #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... Arthritis 69% - Malar ... Auto-Antibodies: - ANA ... : Drug-induced lupus ... #differential #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... infection) - Drugs ... • Infections: Malaria ... #hematology #anemia
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... cases, drug-dependent ... & NPSLE rare, Malar ... #Lupus #DIL #rheumatology ... #diagnosis #treatment
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