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diagnosis differential hematology causes anemia erythematosus hemolysis hemolytic management sle symptoms systemic algorithm autoantibodies bleeding bruising classification hemophagocytic hemostasis hlh
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - Intravascular ... vs Extravascular ... hemoglobinuria (PNH) Extravascular ... usually IgG) (e.g. lupus ... • Infections: Malaria
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm Extravascular ... PK deficiency Intravascular ... Infections • Malaria ... #Hemolysis #Intravascular ... #Extravascular
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Bartonella, Babesia, Malaria ... IVIG infusion Intravascular ... classification #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Arthritis 69% - Malar ... Diagnosis and Lupus ... autoantibodies #signs ... #differential #rheumatology
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
SLE) - Typical Signs ... Alopecia, Fever, Malar ... Adenopathies, Lupus ... Erythematosus #SLE #Signs ... Symptoms #diagnosis #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Leishmaniosis, malaria ... lymphoma (DLBCL, intravascular ... treatment #summary #rheumatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor and lupus ... Willebrand syndrome • Lupus ... , disseminated intravascular ... Differential #Diagnosis #Hematology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
including systemic lupus ... cell lymphoma - Intravascular ... diagnosis #management #rheumatology
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