18 results
diagnosis hematology differential management sle bruising druginduced erythematosus extravascular hemolysis hemolytic hemophagocytic hlh intravascular lymphohistiocytosis oncology summary systemic acidosis activation
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Workup: - ANA ... Manifestations: Malar ... Workup: - ANA ... comparison #table #rheumatology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
for Hemolytic Anemia ... Bartonella, Babesia, Malaria ... MAHA: TTP, HUS, DIC ... #classification ... #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Manifestations: Malar ... of SLE versus DIL ... Positive in 60-80% of cases ... life-threatening • Treatment ... Management #Summary #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... • Infections: Malaria ... disease, Copper and ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Infections • Malaria ... immune-complex hemolytic anemia ... • MAHA (TTP, DIC ... #Hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
& NPSLE rare, Malar ... Workup: - ANA ... Discontinuation of causal ... #DIL #rheumatology ... #diagnosis #treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Non-autoimmune rheumatologic ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
-1 and IL-6, leading ... SJIA], systemic lupus ... with leukopenia, anemia ... Treatment: • Corticosteroids ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Fibrinogen level, ↑ sIL ... Leishmaniosis, malaria ... Drugs, Unknown cause ... Treatment: • ... #summary #rheumatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
What we should be ... perfusion - shock->treatments ... before beginning treatment ... 30mmHg) - Severe anemia ... #typea #typeb #classification
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