24 results
diagnosis differential sle erythematosus systemic management oncology causes hemolytic algorithm classification hemolysis pediatrics peds signs symptoms testing workup activation adverseeffects
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
M DAMN SHARP - Lupus ... Anti-phospholipid) M Malar ... Arthritis R Renal Disease ... sle #systemic #lupus ... erythematosus #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... • Infections: Malaria ... differential #diagnosis #hematology ... #anemia
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... - Hemolytic anemia ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... #differential #rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... deficiency • Fanconi’s anemia ... and Autoimmune Diseases ... : • Systemic lupus ... Differential #Diagnosis #Hematology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
suspicion of severe disease ... and these should ... sweats, pallor, bruising ... - Sickle cell disease ... Rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell disease ... suspected, consider malaria ... ARUPLabs #Hemolytic #Anemia ... Algorithm #workup #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
for Hemolytic Anemia ... Causes: • Liver disease ... Bartonella, Babesia, Malaria ... #Hemolytic #Anemia ... classification #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
, Drugs, Liver Disease ... Infections/toxins: Malaria ... Defects: Sickle cell anemia ... Electrolytes: Wilson's disease ... Differential #Diagnosis #hematology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
B19 infection Malar ... infection • Lyme disease ... migrans • Lyme disease ... lesions • Discoid lupus ... differential #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... manifestations: from easy bruising ... with leukopenia, anemia ... Diagnosis #Management #Hematology ... #Rheumatology
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