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diagnosis erythematosus management differential activation arthritis autoantibodies causes comparison druginduced hematology laboratory macrophage mimickers pediatrics peds purpura rheumatic rheumatoid signs
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Manifestations: Malar ... • Immunologic Workup ... Evolution: Chronic disease ... #lupus #Systemic
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Arthritis 69% - Malar ... - Hemolytic anemia ... #Systemic #Lupus ... #differential #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... • Immunologic Workup ... months to years) Systemic ... Evolution: Chronic disease ... #table #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... manifestations: from easy bruising ... [SLE], AOSD) • ... with leukopenia, anemia ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... (NPSLE): • May ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia ... #Systemic #Lupus
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Purpura or Easy Bruising ... thrombocytopenia) - SLE ... (systemic lupus ... Congenital heart disease ... - Bernard—Soulier
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... lupus erythematosus ... ANAs RF test should ... the presence of anemia
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