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diagnosis sle erythematosus hematology table signs symptoms systemic adverseeffects anemia antibodies antinuclear approach arthritis autoantibodies benefits bruising causes clues defects
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... Auto-Antibodies: - ANA ... (aPL) 30-45% Differential ... Diagnosis and Lupus ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Workup: - ANA ... Manifestations: Malar ... #sle #comparison ... #table #rheumatology
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
joint aches • +ANA ... uncommon 5-15% of lupus ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
should be interpreted ... , Drug-induced Lupus ... , Drug-Induced Lupus ... #patterns #rheumatology ... #diagnosis #differential
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... the face (many differential ... 3) Limb oedema leading ... pericarditis » is...lupus ... erythematosus #rheumatology
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism In contrast to the
Features That Differentiate ... associated with rheumatologic ... presentation of systemic lupus ... trapezius ridges or shoulders ... #Presentation #comparison
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 Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
usually IgG) (e.g. lupus ... • Infections: Malaria ... disease, Copper and ... Extravascular #Causes #differential ... #diagnosis #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... of Hemostasis - Differential ... lupus anticoagulant ... Willebrand syndrome • Lupus ... of factor VII should
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... Photosensitivity • Malar ... Erythematosus #Diagnosis #Rheumatology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
Benefits in Lupus ... other medications leading ... very uncommon but should ... Risks #Benefits #Lupus ... #sideeffects #rheumatology
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