11 results
diagnosis erythematosus management systemic classification differential druginduced treatment activation approach autoantibodies comparison cryoglobulinemia cryoglobulins eularacr hemophagocytic hlh imdamnsharp joint lymphohistiocytosis
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Anti-phospholipid) M Malar ... Antinuclear Antibody (ANA ... cytopenias) A Arthritis ... #IMDAMNSHARP #sle ... erythematosus #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Summary • Epidemiology ... Manifestations: Malar ... versus DIL • ... Workup: - ANA ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Lupus (DIL): ... Constitutional symptoms, Arthritis ... & NPSLE rare, Malar ... , SCLE-DIL (terbinafine ... #table #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria ... • Arthritis domain ... pericarditis • Hematologic ... #SLE #Systemic ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Manifestations: - Arthritis ... 69% - Malar rash ... Auto-Antibodies: - ANA ... Lupusreference #SLE ... #differential #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... Photosensitivity • Malar ... Erythematosus #Diagnosis #Rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Constitutional symptoms, Arthritis ... & NPSLE rare, Malar ... , SCLE-DIL (terbinafine ... Workup: - ANA ... #DIL #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
-1 and IL-6, leading ... erythematosus [SLE ... Histopathologic criteria ... Diagnosis #Management #Hematology ... #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... arthritis) • ... (e.g. systemic lupus ... erythematosus (SLE ... classification #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Fibrinogen level, ↑ sIL ... Leishmaniosis, malaria ... Autoimmune diseases: SLE ... management #treatment #summary ... #rheumatology
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