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diagnosis differential causes hematology bruising blanching bruise dermatology dic disseminated ecchymosis hematomas intravascular leukemoid leukocytosis management petechial physicalexam purpura rash
Bleeding and Bruising - Differential Diagnosis Algorithm • Vascular System Defect - Congenital vs Acquired •
Bleeding and Bruising ... vs Acquired • Platelet ... Qualitative • Coagulation ... vs Acquired #Bleeding ... #pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Intravascular Coagulation ... protein C and S Pathophysiology ... Manifestations of DIC: • Petechiae ... Findings in DIC: • Platelet ... Thrombocytopenia - Platelet
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Differential Diagnosis Algorithm ... Thrombocytopenia - Abnormal platelet ... Complete blood count coagulation ... Differential #Diagnosis #Algorithm
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Sequestration Disordered Platelet ... #Bleeding #Bruising ... Differential #Diagnosis #Algorithm
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Petechiae are ... are typical of coagulation ... lowest levels Platelet ... ability to bind platelets ... Measurement of coagulation
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Differential Diagnosis Algorithm ... B-symptoms, bruising/bleeding ... lymphadenopathy, petechiae ... anemia, ↑ MCV, ↑/↓ platelets ... Differential #Diagnosis #Algorithm
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