1213 results
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation

C	Congestive Heart Failure	1

H	Hypertension	1

A2	Age >75	2

D	Diabetes Mellitus	1

S2	Stroke,
S Stroke 1 B Bleeding ... D Drugs Anti-platelet ... CHADS2VASc #HASBLED #Comparison
Idiopathic Thrombocytopenic Purpura 
Clinical:
 • Gingival 
 • Menorrhagia 
 • GI bleeding 
 • Intracranial
Menorrhagia • GI bleeding ... children) • Platelets ... only for severe bleeding ... extremely low platelet
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... #Defects #comparison
Indications for Transfusion
Packed RBCs
 • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
hemoglobinopathy Platelets ... • < 30,000 and bleeding ... postoperative bleeding ... < 100,000 and bleeding ... Platelet transfusions
Bleeding and Bruising - Differential Diagnosis Algorithm
 • Vascular System Defect - Congenital vs Acquired
 •
Bleeding and Bruising ... vs Acquired • Platelet ... vs Acquired #Bleeding
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... ristocetin • Normal platelet ... count and platelet ... • Platelet flow ... Usually normal platelet
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Differential Diagnosis Platelet ... Diagnosis #causes #Platelets
Thresholds for Transfusion of Platelets in Adults
Major surgery or invasive procedure, no active bleeding - 
≤
Transfusion of Platelets ... procedure, no active bleeding ... neurosurgery, no active bleeding ... Surgery with active bleeding ... #Management #Platelets
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Thrombosis and Bleeding ... Thrombosis Increased Platelet-Vesset ... #Thrombosis #Bleeding
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Thrombocytopenia and Platelet ... History: - Prior platelet ... - History of bleeding ... epistaxis, gingival bleeding ... Thrombocytopenia #Platelet