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management diagnosis comparison pharmacology hematology differential treatment algorithm classification shock checklist causes cardiology clinical medications pulmonary vasopressors pathophysiology risk thrombocytopenia
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
Menorrhagia • GI bleeding ... children) • Platelets ... only for severe bleeding ... extremely low platelet
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... Defects #comparison #table
Indications for Transfusion Packed RBCs • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
hemoglobinopathy Platelets ... • < 30,000 and bleeding ... postoperative bleeding ... < 100,000 and bleeding ... Platelet transfusions
Thresholds for Transfusion of Platelets in Adults Major surgery or invasive procedure, no active bleeding - ≤
Transfusion of Platelets ... procedure, no active bleeding ... Surgery with active bleeding ... 100 (rarely) Stable ... #Management #Platelets
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 Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
WBC and platelets ... Hct 60% Platelet ... Hct < .005) Platelet ... pheresis - Platelets ... Hematology #Management #Table
Bleeding and Bruising - Differential Diagnosis Algorithm • Vascular System Defect - Congenital vs Acquired •
Bleeding and Bruising ... vs Acquired • Platelet ... vs Acquired #Bleeding
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
B-symptoms, bruising/bleeding ... anemia, ↑ MCV, ↑/↓ platelets
Summary of characteristics of Platelet Aggregation Inhibitors #AntiPlatelet #Inhibitors #Pharmacology #Table #Overview #Interactions #Pharmacology #Cardiology
characteristics of Platelet ... #Pharmacology #Table
Disorders of the Hepatic and Mesenteric Circulation Platelets in Cirrhosis Hypercoagulability in Cirrhosis Bleeding in Cirrhosis Portal Vein Thrombosis (PVT) Mesenteric
Circulation Platelets ... in Cirrhosis Bleeding
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease Increased Thrombosis Increased Platelet-Vesset Wall Interaction •
Thrombosis and Bleeding ... Thrombosis Increased Platelet-Vesset ... #Thrombosis #Bleeding
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