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diagnosis hematology management differential algorithm disorders pathophysiology reactions allergy comparison thrombocytopenia transfusion anticoagulation bruising causes criticalcare disease hypersensitivity oncology risk
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
Menorrhagia • GI bleeding ... children) • Platelets ... only for severe bleeding ... extremely low platelet
Indications for Transfusion Packed RBCs • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
hemoglobinopathy Platelets ... Prophylactically for platelet ... not transfuse platelets ... Platelet transfusions ... Management #RBCs #Platelets
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
Platelet disorders ... count and platelet ... (either severe Type ... 1 or Type 3) — ... • Platelet flow
A Classification of Coagulation Disorders #Coagulation #Disorders #Classification #Platelet #Classification #Differential #Diagnosis
A Classification ... Coagulation #Disorders #Classification ... #Platelet #Classification
Thresholds for Transfusion of Platelets in Adults Major surgery or invasive procedure, no active bleeding - ≤
Transfusion of Platelets ... procedure, no active bleeding ... neurosurgery, no active bleeding ... Surgery with active bleeding ... #Management #Platelets
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 Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
common inherited bleeding ... bruising • Skin bleeding ... • Prolonged bleeding ... Laboratory • Normal platelet ... thrombocytopenia in type
Bleeding and Bruising - Differential Diagnosis Algorithm • Vascular System Defect - Congenital vs Acquired •
Bleeding and Bruising ... vs Acquired • Platelet ... vs Acquired #Bleeding
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Bleeding manifestations ... at > 2 weeks Type ... lowest levels Platelet ... ability to bind platelets ... differentiate VWD type
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
to a low blood platelet ... neutrophils and platelets ... Neutropenia • Platelet ... blood cells or platelets ... blood cells or platelets
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease Increased Thrombosis Increased Platelet-Vesset Wall Interaction •
Thrombosis and Bleeding ... Thrombosis Increased Platelet-Vesset ... #Thrombosis #Bleeding
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