22 results
Indications for Transfusion
Packed RBCs
 • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
hemoglobinopathy Platelets ... Prophylactically for platelet ... not transfuse platelets ... Platelet transfusions ... Management #RBCs #Platelets
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... (either severe Type ... 1 or Type 3) — ... Von Willebrand Disease ... considered first-line testing
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... common inherited bleeding ... Laboratory • Normal platelet ... thrombocytopenia in type ... VonWillebrand #Disease
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Sequestration Disordered Platelet ... Coagulation #Bleeding ... Differential #Diagnosis #Algorithm
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Thrombocytopenia and Platelet ... History: - Prior platelet ... - History of bleeding ... smear, HIV/HCV testing ... Thrombocytopenia #Platelet
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
to a low blood platelet ... neutrophils and platelets ... Neutropenia • Platelet ... blood cells or platelets ... blood cells or platelets
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
donor (apheresis) platelets ... transfusion, due to anti-platelet ... common following platelet ... coagulopathy & ↑bleeding ... contamination: Platelets
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... with or without platelet ... , Hemoglobin H disease ... Differential #Diagnosis #Algorithm ... workup #hematology #testing
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
Qualitative defect in platelets ... characteristic of a platelet ... Von Willebrand’s disease ... Von Willebrand disease ... fibrinogen levels, and testing
Mount Sinai COVID-19 Anticoagulation Algorithm

Inclusion: All admitted patients with COVID-19
Exclusion: High risk of bleeding as judged
Anticoagulation Algorithm ... : High risk of bleeding ... as judged by treating ... , consider: - Platelet ... Anticoagulation #Algorithm