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diagnosis hematology differential bleeding disease workup anemia glomerular management nephrology nephrotic aggregometry anticoagulation blanching blood bruise causes coronavirus covid19 disorders
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
Platelet disorders ... count and platelet ... (either severe Type ... 1 or Type 3) — ... considered first-line testing
Bleeding and Bruising - Differential Diagnosis Algorithm • Vascular System Defect - Congenital vs Acquired •
Bleeding and Bruising ... Differential Diagnosis Algorithm ... vs Acquired • Platelet ... #Bleeding #Bruising ... Differential #Diagnosis #Algorithm
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Differential Diagnosis Algorithm ... Symptoms: B-symptoms, bruising ... anemia, ↑ MCV, ↑/↓ platelets ... Differential #Diagnosis #Algorithm
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
of Bleeding / Bruising ... Differential Diagnosis Algorithm ... Sequestration Disordered Platelet ... #Bleeding #Bruising ... Differential #Diagnosis #Algorithm
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
Clinical • Easy bruising ... Laboratory • Normal platelet ... thrombocytopenia in type
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
to a low blood platelet ... neutrophils and platelets ... Neutropenia • Platelet ... blood cells or platelets ... blood cells or platelets
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Excessive bruising ... at > 2 weeks Type ... lowest levels Platelet ... ability to bind platelets ... differentiate VWD type
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Crossmatch - involves testing ... donor (apheresis) platelets ... transfusion, due to anti-platelet ... common following platelet ... contamination: Platelets
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... with or without platelet ... Differential #Diagnosis #Algorithm ... workup #hematology #testing
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... Qualitative defect in platelets ... characteristic of a platelet ... fibrinogen levels, and testing ... #Bleeding #Bruising
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