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hematology syndrome blood hepatorenal hrs product reactions aih algorithm autoimmune chemistry chronic cirrhosis dic differential dili disseminated druginduced failure gastroenterology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Kidney Failure Coagulation ... Injury (DILI) ... #Cirrhosis #Hepatology ... #diagnosis
Hepatorenal Syndrome (HRS) - Diagnostic Criteria HRS-AKI (Acute: previously known as HRS Type 1) • ↑ Creatinine
Syndrome (HRS) - Diagnostic ... (Acute: previously ... structural kidney injury ... - No other cause ... HRSAKI #HRSNAKI #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... for alternative causes ... dechallenge • Acute ... #Injury #Diagnosis ... #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
ALF): • Liver ... injury < 26 weeks ... • Albumin • Coagulation ... #chemistry #diagnosis ... #differential #Hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... DIC • Severe Liver ... #diagnosis #causes ... #treatment #management ... #hematology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
subclinical disease to acute ... liver failure ... injury, though ... Viral) Management ... #Management #Hepatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... fever - ACS, AKI ... , acute limb ischemia ... unless worrisome EKG ... #management #hematology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
hepatitis, or acute ... • Caused by splanchnic ... Diagnosis (Clinical ... causes (esp. ... Hepatorenal #Syndrome #Hepatology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
in recipient (e.g ... Lung Injury (TRALI ... eruptions, diarrhea, liver ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Acute Hemolytic ... Lung Injury (TRALI ... eruptions, diarrhea, liver ... #Transfusion #diagnosis ... #management #hematology
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