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hematology differential algorithm aptt bleeding blood bruising hepatitis hepatorenal hrs nephrology obstetrics pregnancy product prolonged pt reactions syndrome treatment aclf
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
HELLP Syndrome and Acute ... Pregnancy (AFLP) ... child * Severe cases ... #obstetrics #hematology ... #diagnosis #table
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... Algorithm Vascular Causes ... of Acute Liver ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- If both are normal ... • Albumin • Coagulation ... • Near normal ... #chemistry #diagnosis ... #differential #Hepatology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Destruction • Abnormal ... Rare • Drugs (e.g ... Iatrogenic) • Liver ... #Hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Kidney Failure Coagulation ... Injury (DILI) ... Failure #Cirrhosis #Hepatology ... #diagnosis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... = nonspecific (nausea ... iMedEducation #AFLP ... Pregnancy #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... for alternative causes ... dechallenge • Acute ... #Injury #Diagnosis ... #Algorithm #hepatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... amyloidosis #Abnormal ... #diagnosis #differential ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... DIC • Severe Liver ... #diagnosis #causes ... #treatment #management ... #hematology
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