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differential signs hematology treatment lupus systemic arthritis erythematosus joint pain syndrome hemophagocytic hlh leukemia lymphohistiocytosis oncology rheumatoid summary vasculitis workup
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
• Interstitial lung ... • Shrinking lung ... System Tender points ... #differential #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Myositis 4% - Lung ... Lupusreference #SLE ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
effusion, Restrictive lung ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
and Symptoms: ... (interstitial lung ... disease), PAH ( ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... Induced Lupus: • Symptoms ... Chronic B-cell activation ... #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
rash) • Heart, lung ... erythematosus [SLE ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
knees, shoulders Signs ... & Symptoms: • ... • Ultrasound Diagnosis ... : CLINICAL DIAGNOSIS ... #management #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... : SLE+++, Adult-onset ... Still disease, ... #management #treatment ... #summary #rheumatology
Adrenal Insufficiency - Diagnosis and Management Summary Primary Adrenal Insufficiency: Most Common Cause in the US: Autoimmune Adrenalitis Other
and Management ... or metastatic disease ... ketoconazole, etomidate) Symptoms ... Insufficiency: Long-term ... , infiltrative diseases
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
in Sickle Cell Disease ... Generally affects long ... dz difficult to see ... #differential #diagnosis ... #causes #hematology
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