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diagnosis differential dermatology generalized leukemia pruritus secondary systemic aplastic chronic cll disorders emergencies gap globulin hemeonc hemolysis hemolytic hyperpigmentation hypopigmentation
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic Algorithm ... and Causes Increased ... Reticulocytosis/polychromasia ... #Causes #Workup ... #Hematology #Diagnosis
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis Algorithm ... Systemic and Primary Causes ... renal failure/uremia ... Myelodisplastic syndrome ... #causes
Disorders of Pigmentations - Hypopigmentation and Hyperpigmentation - Differential Diagnosis Algorithm HYPOPIGMENTATION Diffuse Congenital - Generalized hypopigmentation of
Differential Diagnosis Algorithm ... of hair, eyes, skin ... sclerosis (white "ash ... McCune Albright syndrome ... #causes
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Diagnosis Algorithm ... deficiency Work ... cryoglobulins • Skin ... #Causes #dermatology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
sudden onset of a rash ... - Rash: multiple ... Causes: - Idiopathic ... , breast CA - Hematologic ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Headaches • Pale skin ... and petechiae Causes ... Constitutional Syndromes ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... Workup: • Complete ... #diagnosis #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... • Neutropenia, anemia ... • Richter’s Syndrome ... Leukemia #diagnosis #workup ... #oncology #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... renal failure/uremia ... Myelodisplastic syndrome ... #generalized #dermatology ... #causes
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... days → add fungal work-up ... ): - Hematologic ... Treat underlying cause ... - CRS: fever, rash
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