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diagnosis hematology management differential causes cancer workup chronic leukemia disease malignancy nephrology pancytopenia pruritus uremia uremic anticoagulation ckd classification cll
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Expectation • Rx Algorithm ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Differential Diagnosis Algorithm ... • Marrow Aplasia ... lncreased WBCs - Polychromatic ... Hemolysis - Polychromatic ... Differential #Diagnosis #Algorithm
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic Algorithm ... Reticulocytosis/polychromasia ... breakdown • Anaemia ... Hemolysis #Hemolytic #Anemia ... #Algorithm #Differential
Causes of Aplastic Anemia #Aplastic #Anemia #Causes #Pathophysiology #Pathology #Treatment #Management #Differential
Causes of Aplastic ... Anemia #Aplastic ... #Anemia #Causes ... Pathophysiology #Pathology #Treatment
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... mutations) • Immune Aplastic ... anemia Treatment ... #Anemia #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... • Symptomatic anemia ... Treatment: • Consider ... Medicine @SCVMCMed #Aplastic ... #management #treatment
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... to Anemia - Differential ... Non-hemolytic: ACD, Aplastic ... anemia, CKD • ... #MCV #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... lead poisoning • Polychromasia ... decrease - PNH • Polychromasia ... ARUPLabs #Hemolytic #Anemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... only curative treatment ... Diagnosis #Management #treatment ... #hematology #oncology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Differential Diagnosis Algorithm ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... Differential #Diagnosis #Algorithm
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