2782 results
Addictions: Long-Term Social Consequences
 • Public stigma
 • Self-stigma
 • Decreased self-esteem and self-efficacy
 • Loss
Homelessness • Cycle of poverty
Driving Impairment in Cirrhosis and Hepatic Encephalopathy 
 - Advise patients not to drive ~3 months
months after last overt ... without prior overt ... Encephalopathy #management
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
dementia, Ataxia, Poverty
Short Stature - Differential Diagnosis Algorithm
Normal Variant, Normal Puberty Onset (BA = CA)
 • Familial Short
Variant, Normal Puberty ... Variant, Delayed Puberty
Gynecomastia - Differential Diagnosis a
nd Workup Algorithm
Gynecomastia is common in clinical practice, affecting ~50% of males
50% of males in puberty
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
apparent at or before puberty ... • Precocious puberty
Causes of Copper Deficiency - Differential Diagnosis
Hereditary: 
 - Menkes disease, familial hypoceruloplasminemia
Decreased / Inadequate Intake:
, Kwashiorkor, poverty
Algorithmic Approach to Hypothyroidism - Differential Diagnosis and Management Framework

Central Hypothyroidism (Secondary or tertiary) ↓TSH, ↓FT4
Diagnosis and Management ... Immunologic lesions Overt ... #hypothyroid #Management
Causes of Failure to Thrive - Differential Diagnosis Algorithm
Adequate Calorie Consumption
 - Increased Losses:
Neglect • Poverty
Tall Stature - Differential Diagnosis Algorithm

Normal Growth (BA=CA)
 • Familial Tall Stature
 • XYY Syndrome
Obese BMI
Obesity Normal Puberty ... Hyperthyroidism Precocious Puberty