28 results
Cephalosporins 
Cephalosporins are bactericidal beta-lactam antibiotics derived from the fungus Acremonlum— they disrupt peptidoglycan formation in
Cephalosporins are ... They have no activity ... predominantly active ... #Generations #Classification ... #pharmacology #
Important Cardiac Transplant Medications and Side Effects
 • Cyclosporine (Sandimmune, generic) - Calcineurin inhibitor, decreasing T
decreasing T lymphocyte activity ... prophylaxis against rejection ... production of pro-inflammatory ... Decreases T cell activity ... Medications #drugs #pharmacology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Vaughan Williams Classification ... node and AV node activity ... Vaughan #Williams #Pharmacology ... #Classification ... #Classes #pathophysiology
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
thrombophilias are ... surgery, trauma, active ... - No other workup ... Hypercoagulable #Workup ... hematology #diagnosis #algorithm
GLP-1 Agonists

Adlyxin (Lixisenatide) Daily
Bydureon (Exenatide ER) Weekly 
Ozempic (Semaglutide) Weekly 
Trulicity (Dulaglutide) Weekly 
Victoza (Liraglutide) Daily
They work primarily ... upset (since it works ... GI tract) and injection ... That's because they work ... GLP1 #Agonists #Pharmacology
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... interferes with the activity ... mitochondrial electron ... kidney injury are
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... Vaughan Williams Classification ... node and AV node activity ... #Classification ... #Classes #pathophysiology
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
Fatigue and IBD Algorithm ... Pearls: • IDA and active ... NRH & Heme eval. re ... ileal Crohn's/resection ... have fatigue w/ active
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Antigen-antibody complexes are ... tissues where they activate ... Antigen-presenting cells activate ... Tuberculin test, Graft rejection ... allergy #table #classification
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... tumour B cells are ... Lymphoproliferative #Disorders #Classification ... #pathophysiology ... #differential #algorithm