6 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Agglutinin Syndrome ... (CAS): - Due ... Viral Infection Clinical ... Positive Coombs testing ... hemolytic #anemia #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... (for secondary APS ... Erythematosus #SLE #CNS
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
) - Symptoms: CNS ... ) - Symptoms: CNS ... (CRS) / ICANS: ... 2–4 days after CRS ... AML (~20 %) and APL
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
IL-1 and IL-6, leading ... Clinical Presentation ... Fever is the main clinical ... nervous system (CNS ... #Diagnosis #Management
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
(SPS) - Diagnosis ... brain and spinal cord ... Clinical Manifestations ... positive in 2/3 of pts ... antibody that works
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm
INDICATIONS FOR TESTING:
 • Vascular thrombosis
Antiphospholipid Syndrome ... (APLS) Testing ... - 1 or more clinical ... #Algorithm #diagnosis ... #hematology