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liver transaminitis algorithm interpretation tests chemistry drug elevation functiontest gastroenterology hepatitis idiosyncratic induced laboratory management rvalue values
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Differential Diagnosis ... (>1000): • DILI ... Drug-induced liver injury ... #Tests #LFTs #Differential ... #Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... #Diagnosis #Management ... gastroenterology #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... abnormality vs bone Bili ... Transaminitis #diagnosis ... #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... (LFTs) - Normal ... hepatocellular injury ... Interpretation #diagnosis ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... • Iatrogenic: DILI ... Tests of synthetic function ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis ... #LFTs #RValue #
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