12 results
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... , Palpable purpura ... • Palpable purpura ... Vesicles overlying purpuric ... Henoch-Schönlein purpura
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Small Vessel: Petechiae ... , Palpable purpura ... Vasculitis: - Ig A (HSP ... Vasculitis: • Behcet Disease
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
poor nutrition Clinical ... • Purpura • Perifollicular ... • Petechiae, purpura ... Henoch-Schonlein purpura ... #VitaminC #AscorbicAcid
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis: • Purpura ... purpura: Strong ... purpura • Pauci ... purpura, joint ... purpura (lower
Diagnosis of IgA Vasculitis (Henoch-Schönlein Purpura) - French Vasculitis Study Group 

1) Suggestive clinical manifestations
Henoch-Schönlein Purpura ... - Symmetric palpable ... purpura mainly ... - Systemic disease ... HenochSchonleinPurpura #HSP
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Pathogenesis and Clinical ... endothelial cells - Palpable ... or necrotic purpura ... PolyarteritisNodosa #Pathophysiology ... #Diagnosis #Signs
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... • Purpura • ... Palpable variants ... Hemorrhagic bullae • Purpura ... • Severe Liver Disease
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
Pathogenesis and Joint diseases ... boggy" joints, esp ... Extra-articular signs ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... rash, Vasculitis, Purpura ... Aseptic necrosis of hip ... pain (20%) Renal disease ... erythematosus #signs
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Fever is the main clinical ... easy bruising to purpura ... mucosal bleeding (Petechial ... or purpuric rash ... 5000 to 10,000 ng/mL