17 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... PURPURA: Platelet ... Acute Infectious Purpura ... PURPURA: Vasculitis ... #hematology #rheumatology
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
Diagnosis of Cryoglobulinemia ... • Vascular purpura ... #Vasculitis #Diagnosis ... #Rheumatology # ... Cryoglobulinemic
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
infectious mixed cryoglobulinemia ... vasculitis - Diagnosis ... involvement with purpura ... #Vasculitis #Rheumatology ... #Diagnosis #Management
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
purpura (16%) ... purpura • Vesicles ... overlying purpuric ... Henoch-Schönlein purpura ... #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Arthralgia - Purpura ... Clinical triad of Palpable ... purpura, Arthralgia ... Henoch-Schönlein purpura ... classification #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
- Differential Diagnosis ... Vessel: Petechiae, Palpable ... purpura, Hemorrhagic ... Urticarial/LCV) - Cryoglobulinemic ... #rheumatology #
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Crohn's disease Palpable ... purpura • Hypersensitivity ... Henoch Schönlein purpura ... #differential #diagnosis ... #rheumatology
Cryoglobulinemia Classification Types

Type 1: Monoclonal IgM (rarely IgG/lgA)
 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Cryoglobulinemia ... Meltzer's triad: purpura ... MatthewHoMD #Cryoglobulinemia ... Classification #Types #hematology ... #diagnosis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Lupus Nephritis, Cryoglobulinemia ... Henoch-SchonIein Purpura ... #differential #diagnosis ... #algorithm #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis: • Purpura ... purpura: Strong ... purpura • Pauci ... purpura, joint ... #Rheumatology