476 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
nephrocalcinosis • CPPD ... • Inorganic pyrophosphate ... PPi (inorganic pyrophosphate ... respiratory failure • Neurologic ... Phosphatase: • Other causes
Pseudogout: pathogenesis and clinical findings
 - Idiopathic (vast majority of cases) -> Mechanism unknown
 - Familial
vast majority of cases ... ANKH gene, Incr pyrophosphate ... dihydrate (CPPD ... and/or x-ray - CPPD ... Chondrocalcinosis #Pseudogout #CPPD
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Summary - Calcium Pyrophosphate ... Pathophysiology: Pyrophosphate ... calcium to form CPP ... Chronic calcium pyrophosphate ... #Calcium #Pyrophosphate
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
CPPD vs Gout ... == CPPD == Think ... About CPPD When ... Pathophysiology: • Pyrophosphate ... Asymptomatic CPPD
Pathogens in Pneumonia

Here is a quick review of the pathogens causing pneumonia (useful for enumerating differentials
your grand rounds/cases ... H. influenzae (COPD ... Pseudomonas — COPD ... Legionella spp (COPD ... #Microbiology #Causes
Hypoxemic Respiratory Failure - Differential Diagnosis Framework
DECREASED INSPIRED OXYGEN
 • Low PATM Can decrease first part
average settings • Causes ... gas equation • Causes ... respiratory drive due to neurologic ... • Most common cause ... Pneumonia, asthma, COPD
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy
 • Central or peripheral neurologic disease
Causes of Proximal ... or peripheral neurologic ... #differential #causes ... #neurology
Causes of Dizziness - Vertigo - Differential Diagnosis Algorithm
True Vertigo - Illusion of Rotary Movement
Peripheral Vestibular
Causes of Dizziness ... Dysfunction - Nausea ... Dysfunction - Imbalance, neurologic ... Dizziness #Vertigo #Neurology ... Diagnosis #Algorithm #Causes
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
proteinuria, RBC casts ... → Refer to Nephrology ... and referral to Urology ... if cause not identified ... Algorithm #Workup #urology
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
: CHF, valves, COPD ... Differential #Diagnosis #causes ... #neurology