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diagnosis anemia differential hematology workup aafp anemias antibody causes cold disease folate folicacid homocysteine macrocytosis management mcv mma rheumatology testing
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Differential Diagnosis Algorithm ... Abnormal peripheral smear ... : • Autoimmune ... • Extrinsic RBC ... • Intrinsic RBC
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... AIHA • Anemia: macrocytic ... ↑ LDH • Anti-RBC ... C3d • Blood smear ... diagnosis #management #treatment
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... IgM) • Blood smear ... - RBC agglutination ... CLL (older) • Autoimmune ... red blood cells (RBCs
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Differential Diagnosis Algorithm ... Peripheral blood smear ... Hypochromic & microcytic ... RBCs, DAT (-) → ... idiopathic, malignancy, autoimmune
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... -100): • Non-hemolytic ... Spherocytosis, G6PD, PK, HbC ... - Extrinsic: Autoimmune ... Infections Macrocytic
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold agglutinins ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... elliptocytosis, autoimmune
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
Algorithm for the ... evaluation of macrocytic ... (RBC = red blood ... ordering a peripheral smear ... Hemorrhage or hemolysis
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