810 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... Blood smear - RBC ... red blood cells (RBCs ... passage of red-brown urine
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... Microangiopathic Hemolytic Anemias ... #Normocytic #Anemia
Urine Microscopy and Casts - Image Atlas Key

- Squamous Epithelial Casts
- Transitional Epithelial Cells
- Renal Tubular
Urine Microscopy ... - Monomorphic RBCs ... - Dysmorphic RBCs ... - WBC Cast - RBC ... JoseTesser) #Urine
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Urinalysis >3 RBCs ... WBCs, or urine ... → Urine culture ... (proteinuria, RBC ... casts, dysmorphic RBCs
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... / Normochromic RBCs ... Deficiency • Aplastic Anemia ... • Anemia of Chronic ... Non-lmmune #Anemia
Pathophysiology of Hemolytic Anemia
 - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects)
 -
Pathophysiology of Hemolytic Anemia ... - Defects in RBC ... - Defects in RBC ... Defects in the RBC's ... Pathophysiology #Hemolytic #Anemia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Neutrophils - Low RBC ... • Pernicious Anemia ... RBCs in Rouleaux ... #Macrocytic #Anemia
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
glomerular hematuria (RBC ... or dysmorphic RBCs ... in urine)?
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... • Extrinsic RBC ... • Intrinsic RBC ... #Hemolytic #Anemias
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (MCV): Average RBC ... among size of RBCs ... for degree of anemia ... thecurbsiders podcast #Anemia