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diagnosis rheumatology erythematosus differential management systemic classification nephrology vasculitis criteria druginduced glomerulonephritis nephritis treatment antidsdna arthropathies arthropathy biomarkers biopsy champs
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Hypocomplementemia - CHAMPS ... S - Systemic Lupus ... Hypocomplementemia #Low #Complement ... #CHAMPS #Mnemonic
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... Lupus (DIL): ... 90% - Low complement ... 80% - Low complement ... management of SLE
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... , oral ulcers, Lupus ... 80% - Low complement ... #lupus #Systemic
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Criteria - Systemic Lupus ... ACUTE CUTANEOUS LUPUS ... anticoagulant - Low complement ... #Rheumatology #SLE
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... (SLE): Pathogenesis ... HLA-DR3 genes, complement ... #Systemic #Lupus ... Erythematosus #SLE
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Criteria for Systemic Lupus ... Acute cutaneous lupus ... anticoagulant • Complement ... Classification #Criteria #SLE ... #Systemic #Lupus
Lupus - Role of complement and anti-dsDNA for the detection of flares Complement - ↓ Decreased Anti-dsDNA -
Lupus - Role of ... complement and anti-dsDNA ... detection of flares Complement ... Increased #Lupus ... #SLE #flares #laboratory
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... RNP antibodies, Complement ... : Drug induced SLE ... SSA can rule in SLE
Approach to managing Glomerulonephritis (GN) in children. ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
cytoplasmic antibodies; SLE ... , systemic lupus ... Glomerulonephritis #Algorithm
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