15 results
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
Supportive with treatment ... hepatomegaly and anemia ... Supportive with blood ... failure • Supportive ... Hepatobiliary #hepatology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
of fibrin-split products ... deficiency - Anemia ... leads to chronic anemia ... ; blood loss from ... LiverFailure #Hepatic #Hepatology
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Insufficiency, Liver ... Failure, Toxins ... Medications, Spinal Cord Injury ... • Hypovolemic: Blood ... Differential #Diagnosis #criticalcare
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... hypoTN, renal failure ... Related Acute Lung Injury ... eruptions, diarrhea, liver ... Blood products contain
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
removal from the blood ... or renal injury ... before beginning treatment ... 30mmHg) - Severe anemia ... Injury: • Reduced
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Marrow (Toxic injury ... and petechiae Causes ... Treatment: ... result from low blood ... #oncology #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... Out Secondary Causes ... Marrow Failure ... factor (GCSF) treatments ... Syndromes #diagnosis #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
hypoTN, renal failure ... Causes purpura & ... Related Acute Lung Injury ... eruptions, diarrhea, liver ... Blood products contain
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver ... • Pernicious anemia ... deficiency • blood ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
with leukopenia, anemia ... thrombocytopenia • Liver ... Fibrin degradation products ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology