13 results
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
• Associated Findings ... Spherocytes • Treatment ... • Associated Findings ... transient hemolysis • Treatment ... #hematology #diagnosis
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
1) DIAGNOSE AIHA ... • Anemia: macrocytic ... FOR a cause → Systematic ... #diagnosis #management ... #treatment #rheumatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... solid cancers • Systemic ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
physical exam findings ... • Homogeneous: Systemic ... , Interstitial Pulmonary ... ANA #patterns #rheumatology ... #diagnosis #differential
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
processes: • Systemic ... thrombophlebitis, pulmonary ... Cryofibrinogenemia Diagnosis ... #rheumatology # ... hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
with leukopenia, anemia ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... complaints- anemia ... of the steroid treatment ... Treatment of GCA ... them, but urgent rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... progressing GN • New pulmonary ... Differential Diagnosis ... discrepancies Findings ... #rheumatology #
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
rendering the immune system ... ’s CLL Scoring system ... • Neutropenia, anemia ... microglobulin Treatment ... workup #oncology #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
and laboratory findings ... Differential Diagnosis ... Non-autoimmune rheumatologic ... lymphopenia, low PLT • Anemia ... #Rheumatology