5 results
Whipple Disease (Tropheryma whipplei) - Diagnosis and Management 

Caused by: Tropheryma whipplei

Symptoms and Signs:
1. Migratory poly/oligoarthralgia
Whipple Disease ... Criteria - Either ... Oculomasticatory/oculo-facial-skeletal ... • PAS-positive macrophages ... #diagnosis #algorithm
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... thrombocytopenia • Liver ... function tests ... Histopathologic criteria ... #Diagnosis #Management
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
tests algorithm ... metabolic syndrome criteria ... disease; AST, aspartate ... disease; T2DM, ... LFTs #Abnormal #Algorithm
Amyloidosis - Summary
Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Clinical suspicion ... the extent of disease ... Inflammation → Macrophage ... activation → IL ... imaging of liver
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
▪ Autoimmune diseases ... termed MAS-HLH: Macrophage ... Clinical Presentation ... - Elevated liver ... Diagnostic Criteria