11 results
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... connective tissue disease ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... rheumatology #diagnosis #differential
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... : Lupus (SLE), Systemic ... Lymphoproliferative Disorders ... Kumfer @AnnKumfer #Antinuclear ... rheumatology #diagnosis #differential
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... with MCTD and Raynaud's ... with auto-immune diseases ... Lupusreference #Antinuclear
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Photosensitivity 29% - Raynaud's ... involvement 3% SLE-Related ... Auto-Antibodies ... (aPL) 30-45% Differential ... Lupusreference #SLE
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
- Differential Diagnosis ... Algorithm Monoarthritis ... with Systemic Lupus ... Erythematosus (SLE ... #msk #Differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... ) • Endocrine disorders ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Petechial Rash - Differential ... Diagnosis Algorithm ... Vasculitis - Collagen disorders ... Autoimmune Vasculitis (lupus ... Measurement of antinuclear
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Diagnosis Algorithm ... • Anti-GBM antibodies ... (MPA) • SLE ... Minimal change disease ... #Proteinuria #Nephrology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Studies in Rheumatic Diseases ... joint • Systemic lupus ... ) - Antinuclear ... double-stranded DNA antibodies ... metabolic or endocrine disorders
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Evaluate for NMO, SLE ... : - SLE - Neurosarcoidosis ... Antiamphiphysin antibodies ... diagnosis #management #neurology ... #differential