8 results
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... with MCTD and Raynaud's ... Lupusreference #Antinuclear ... #autoantibodies
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... severe disease Treatment ... #rheumatology #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... the formation of autoantibodies ... Puncture, EEG Treatment ... cerebritis #diagnosis #management ... #treatment
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... months) and of autoantibodies ... life-threatening • Treatment ... Usual therapeutic management ... rheumatology #diagnosis #management
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
with response to treatment ... serum lgE, no autoantibodies ... (antinuclear antibodies ... IgG4+ cells" Treatment ... Disease #diagnosis #management
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
Diagnosis and Management ... disorders • Testing ... diazepam • EMG testing ... CRP • Other autoantibodies ... #treatment #neurology
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... constitutional symptoms • Treatment ... months) and of autoantibodies ... rheumatology #diagnosis #treatment ... #management
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
ab • RF • Antinuclear ... Cryoglobulinemia (4%-12%), Raynaud ... Adenocarcinoma Treatment ... Rheumatology #Diagnosis #Management