151 results
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia
Clinical
 - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
of autoimmune disease ... Immunophenotype: - Positive ... : CD2, CD3, CD8 ... morphologic/clinical disease ... hemepath #pathology #diagnosis
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
reaction - Atopic disease ... CD3-CD4+ T cells ... , IgG4-related disease ... hypereosinophilia #HE #Differential ... #Diagnosis #Causes
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
in HIV / AIDS - Differential ... Diagnosis Framework ... Demyelinating disease ... and <25% culture positive ... CNS #Infections #differential
Upper lung zone preference is seen in:
- Inhaled particles: pneumoconiosis (silica or coal)
- Smoking related diseases
Smoking related diseases ... bronchiolitis (RB-ILD ... Pulmonary edema #Diagnosis ... HRCT #ChestCT #Differential
Interstitial Lung Diseases (ILD)
Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): 
 • Hypersensitivity pneumonitis, Farmer's lung, Bird
Interstitial Lung Diseases ... Connective Tissue Disease ... (RB-ILD), Desquamative ... #ILD #diagnosis ... #differential #
Multi-System Inflammatory Syndrome in Children (MIS-C) vs. Kawasaki Disease
CDC Case Definition for MIS-C;
 • < 21
Kawasaki Disease ... CDC Case Definition ... other reasons for disease ... • Positive COVID ... Kawasaki #Comparison #diagnosis
Hypocalcemia - Diagnosis and Management
PTH Independent (↑ PTH)
 • LOW VIT D
    -
Hypocalcemia - Diagnosis ... and Management ... , Kidney Disease ... (CKD) - Metabolism ... #differential #
Hyperthyroidism (low TSH, High T4/T3) - Diagnostic Algorithm

Radioactive iodine scan – get if concern for nodular
nodular thyroid disease ... Graves disease – ... specific, so if positive ... Graves disease! ... workup choices AND management
Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
- Hx of AKI/CKD ... US w/ PVR - CPK ... - Pre-renal disease ... AKI #Nephrology #Diagnosis ... Algorithm #Causes #Differential
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... fraction < 20% Differential ... Diaqnoses: • ... Muscular: normal CK ... #diagnosis #management