1435 results
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Delayed autoimmune reaction ... Activation of auto-reactive ... RheumaticFever #pathophysiology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
constipation • Allergic reaction ... mediated cytotoxic reaction ... #SideEffects #Pathophysiology
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
on the Kidney - Pathophysiology ... Idiosyncratic immune reaction ... nephrology #Effects #pathophysiology
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Immune Reactions ... #Pharmacology #Pathophysiology
Allergic Rhinitis: Pathogenesis and clinical findings

1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Primary Reaction ... Secondary Reaction ... after the primary reaction ... Rhinitis #Rhinorrhea #pathophysiology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
- Transfusion Reactions ... blood donor • Pathophysiology ... transfusion • Pathophysiology ... #Transfusion #Reactions
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
hypersensitivity reaction ... #Anaphylaxis #pathophysiology
Pathophysiology of ACE inhibitor-induced angioedema: Angioedema is a vascular reaction associated with tissue (subcutaneous, submucosal) edema
Pathophysiology ... is a vascular reaction
Pathogenesis of Rheumatic Fever

Pathogenesis of rheumatic fever. 
1. GAS pharyngitis leads to antigenic presentation of pathogenic
development of cross-reactive ... antibodies and cross-reactive ... activation' by cross-reactive ... Rheumatic #Fever #Pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Allergic reaction ... Allergy #Immunology #pathophysiology