9 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Clotmaster #VTE #DOAC ... Rivaroxaban #Edoxaban #Loading ... #DVT #Pharmacology ... #Hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
) Cancer-treatment ... thereby leading ... metabolization leading ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
Migraine - Preventative Treatments

 • Anticonvulsants: *Topiramate, *Sodium valproate, Gabapentin, Pregabalin
 • Antidepressants: Amitriptyline, Venlafaxine, Duloxetine,
Migraine - Preventative ... Treatments ... #prophylaxis #prevention ... #pharmacology # ... neurology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... not available #DOAC ... anticoagulant #hematology ... #management #pharmacology
Triptan Selection - Migraine Management
Choosing triptans:
 • Reponse to given triptan do not predict to others
Triptan Selection - Migraine ... response: • Consider preventive ... #Management #treatment ... #neurology #pharmacology ... selection #headache #neurology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
inflammation, leading ... Puncture, EEG Treatment ... APS), Secondary prevention ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
Aimovig (Erenumab)
Mechanism: Calcitonin Gene-related Peptide Receptor Antagonist 
Indication: Preventive Treatment of Migraines:
Dosing: 70 mg SQ monthly,
Indication: Preventive ... Treatment of Migraines ... monthly to prevent migraines ... Aimovig #Erenumab #Migraine ... #Neurology #Pharmacology
Complications after Bariatric Surgery
Post Bariatric Intestinal Failure:
 • Severe protein malnutrition after bariatric surgery
 • More
nutrients • TPN for treatment ... inuslin release leading ... excluded limb • Treatment ... and prevention ... Gastroenterology and Hepatology
Hepatic Encephalopathy - Diagnosis and Management Summary
Definition:
 • Alteration in brain function manifested by neuropsychiatric symptoms
other causes of neurologic ... noxious stimuli) TREATMENT ... Initiate empiric treatment ... Encephalopathy #Grading ... #hepatology