161 results
Initial treatment of renal bone disease and cinacalcet for secondary hyperparathyroidism
Phosphate binders reduce hyperphosphataemia and hyperparathyroidism.
Initial treatment ... Phosphate binders reduce ... the first-line treatments ... hyperparathyroidism which reduces ... #Pharmacology #Pathophysiology
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
pharyngeal erythema, fever ... pharyngeal erythema, fever ... bacterial metabolites induce ... Sudden onset of fever ... pruritic rash, fever
Treatment of Wilson's Disease
 • D-penicillamine - Chelator, induces cupruria
 • Trientine - Chelator, induces cupruria
Treatment of Wilson's ... Tetrathiomolybdate - Aims to reduce ... Wilsons #Disease #Treatment ... #management #pharmacology
Summary of actions of some Cholinergic Agonists

Bethanechol 
• Used in treatment of urinary retention 
• Binds
Bethanechol • Used in treatment ... Used topically to reduce ... Pilocarpine • Reduces ... been shown to reduce ... Cholinergic #Agonists #Pharmacology
Drugs that Cause Fever
Most commonly:
Amphotericin B, Antihistamines, Asparaginase, Barbiturates, Bleomycin sulfate, Methyldopa, Penicillins, Phenytoin sodium, Procainamide,
Drugs that Cause ... Fever Most commonly ... hydrochloride #Drug #Fever ... #causes #differential ... #diagnosis #pharmacology
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
Fever vs Hyperthermia ... Fever: • Regulated ... production • Treatment ... rapidly fatal • Causes ... BrighamChiefs #Fever
Bradycardia - Differential Diagnosis Framework

BRADI Mnemonic
 • BRASH/Hyperkalemia
 • Reduced oxygen/Glucose/Temp
 • ACS
 • Drugs
 •
Hyperkalemia • Reduced ... Acute rheumatic fever ... • Yellow fever ... Spondylarthropathies Other causes ... differential #diagnosis #causes
Causes of Iron Deficiency
 • Inadequate Intake: Vegetarian/vegan diet, Malnutrition
 • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Pregnancy, EPO treatment ... Coagulopathy, Steroids • Reduced ... differential #diagnosis #causes
“Step by Step” – the new kid on the block – aims to risk stratify this
group to both reduce ... investigations and treatments ... an infant with fever ... Stratification #Fever
Hydroxyurea - Pathophysiology and Benefits in Sickle Cell Disease
 • Decreases number of pain crises (
number of pain crises ... (2.4 vs. 1) • Fewer ... 35% vs. 24%) • Fewer ... pathophysiology #pharmacology