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differential causes elevatedmcv macrocytosis microcytic calculation index mcv normocytic production reticulocyte thrombocytopenia workup
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... Non-hemolytic: ACD, Aplastic ... Infections Macrocytic ... aciduria, Drugs (e.g ... #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... width: Measures degree ... of substrate (e.g ... #Algorithm #Diagnosis ... #Workup #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
- Differential Diagnosis ... Algorithm Decreased ... • Marrow Aplasia ... • Secondary (e.g ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Anemia • Toxic ... Damage (e.g. ... Displacement (e.g ... Foreign Surface (e.g ... #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Algorithm Normal ... • Drugs Oval Macrocytes ... Increased Requirement (e.g ... #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
at a particular degree ... marrow failure: Aplastic ... infiltration (e.g ... Marrow suppression (e.g ... Intrinsic RBC defects (e.g
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Algorithm Decreased ... Iron Deficiency (Eg ... Other • e.g ... #Microcytic #Anemia ... #Hematology
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