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diagnosis hematology algorithm bruising pt bleeding intravascular anemia dermatology disorders extravascular hemolysis hemolytic hemorrhage hemostasis inr management obgyn obstetrics pediatrics
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Disseminated intravascular ... coagulation (DIC ... #PT #aPTT #Prolonged ... #differential #
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
hemorrhage • Disseminated ... intravascularcoagulation (DIC ... amyloidosis #Abnormal ... #PT #aPTT #Prolonged ... hematology #coagulation
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT, Normal PT ... PTT, Normal PT ... #PPT #PT #INR #Differential ... #Hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Coagulation (DIC ... Thrombocytopenia • Prolonged ... #Disseminated # ... #diagnosis #causes
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... . prolonged/induced ... succenturiate lobe • Abnormal ... HELLP syndrome • Disseminated ... (DIC) • Anti-coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... / Bruising - Differential ... Destruction • Abnormal ... Rare • Drugs (e.g ... Deficiency • Disseminated
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/ABNORMAL PTT ... the PT remains prolonged ... ABNORMAL PTT: Prolongation ... liver failure, disseminated ... discern these causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): - Disseminated ... intravascular coagulation ... (DIC) - HELLP ... #differential #
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... Meningococcemia - Disseminated ... fulminans - DIC ... Complete blood count coagulation
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... purpura - DIC ... (disseminated intravascular ... coagulation) ... pediatrics #diagnosis #differential
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