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hematology abnormal bruising intravascular pt algorithm anemia arterial bleeding extravascular hemolysis hemolytic hemorrhage hemostasis management obgyn obstetrics pediatrics peds postpartum
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Disseminated intravascular ... coagulation (DIC ... #Prolonged #Causes ... #diagnosis #differential
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... hemorrhage • Disseminated ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... arterial clot, ... endocarditis) - Disseminated ... intravascular coagulation ... #Diagnosis #clots
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Coagulation (DIC ... Thrombocytopenia • Prolonged ... significant fibrin clot ... INR < 2.3 - APTT ... #diagnosis #causes
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... . prolonged/induced ... Retained blood clots ... HELLP syndrome • Disseminated ... (DIC) • Anti-coagulation
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): - Disseminated ... intravascular coagulation ... (DIC) - HELLP ... #differential #
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... Diagnosis Framework ... the PT remains prolonged ... liver failure, disseminated ... discern these causes
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
purpura - DIC ... (disseminated intravascular ... coagulation) ... peds #pediatrics #diagnosis ... #differential #
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