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diagnosis hematology abnormal algorithm bruising dermatology intravascular nonpalpable palpable prolonged pt anemia bleeding disseminated extravascular hemolysis hemolytic hemorrhage hemostasis management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Petechiae • Purpura ... Hemorrhagic bullae • Purpura ... Treat primary cause ... INR < 2.3 - APTT ... #diagnosis #causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... marrow disease - DIC ... Defects: • DIC ... Fulminans (DIC ... #Differential #
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... (DIC) c. ... #Prolonged #Causes ... #diagnosis #differential
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... the PT and the aPTT ... intravascularcoagulation (DIC ... #diagnosis #differential ... #hematology #coagulation
Causes of Purpura - Differential Diagnosis Non-PalpabIe → Palpable • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... - Differential ... HIT, ITP/HUS), Coagulation ... defects (DIC, warfarin ... #Differential #
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Hemorrhage - Differential ... thrombocytopenic purpura ... thrombocytopenic purpura ... (DIC) • Anti-coagulation
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... (DIC) - HELLP ... thrombocytopenic purpura ... #differential #
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... Henoch Schonlein Purpura ... fulminans - DIC ... Complete blood count coagulation
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... - DIC (disseminated ... intravascular coagulation ... #Bruising #Causes ... pediatrics #diagnosis #differential
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... Warfarin • Acute DIC ... discern these causes ... disease • Acute DIC
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