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diagnosis differential coagulation abnormal aptt algorithm anemia arterial bleeding bruising hemolysis hemolytic hemorrhage hemostasis isth laboratory management obgyn obstetrics postpartum
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... intravascular coagulation ... (DIC) - HELLP ... hemoglobinuria (PNH) Extravascular ... #Extravascular
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... arterial clot, ... endocarditis) - Disseminated ... intravascular coagulation ... #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation ... (DIC) Platelet ... thrombin to form clots ... Intravascular #Coagulation ... Scoring #diagnosis #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... Disseminated intravascular ... coagulation (DIC ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Thrombocytopenia • Prolonged ... significant fibrin clot ... Intravascular #Coagulation ... treatment #management #hematology
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
. prolonged/induced ... Retained blood clots ... HELLP syndrome • Disseminated ... intravascular coagulation ... (DIC) • Anti-coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and aPTT If ... the PT and the ... hemorrhage • Disseminated ... intravascularcoagulation (DIC ... #differential #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
prolonged after ... liver failure, disseminated ... intravascular coagulation ... discern these causes ... Differential #Diagnosis #Hematology
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