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differential lupus erythematosus joint pain systemic table activation antibodies approach autoantibodies behcet chronic cll conditions cppd dermatology druginduced extrarticular igg4
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Nodules • RA • Gout ... Tophi - Gout ... , Reactive arthritis ... #differential #diagnosis ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... likely it will be clinically ... , Sjögren Syndrome ... #patterns #rheumatology ... #diagnosis #differential
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
(Clinical Dx). ... , Reactive arthritis ... : SLE, Reactive ... #diagnosis #management ... signs #symptoms #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... , a negative ANA ... of reactive arthritis ... and RF (if clinical ... #Rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... is clinically suspected ... overlap syndromes ... erythematosus #diagnosis ... #rheumatology #
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... 40, F:M 9:1 • Clinical ... • Immunologic Workup ... : Chronic disease ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... : Chronic disease ... #comparison #table ... #rheumatology # ... diagnosis #management
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Clinical history ... autoantibodies (antinuclear ... #diagnosis #management ... #phenotypes #workup ... #treatment #rheumatology
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
• Underlying disease ... • Metabolic syndrome ... • ↑ C-reactive ... #Comparison #rheumatology ... #Diagnosis
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
to Joint Pain - Diagnostic ... arthritis, gout ... Chronic = RA, SLE ... Joint #Pain #MSK #rheumatology ... #approach #workup
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