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diagnosis myositis autoimmune differential management systemic ana anca antibody antineutrophil antinuclear antinxp2 antinxp2dm arthritis classification clinical cutaneous dermatology diseases erythematosus
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific Antibodies ... (MSAs) Dermatomyositis ... Mediated Necrotizing Myopathy ... Myositis #Specific #Antibodies ... clinical #diagnosis #rheumatology
Cutaneous and Systemic Findings in Dermatomyositis Cutaneous Findings: - Heliotrope sign and edema - Nail-fold changes -
Systemic Findings in Dermatomyositis ... or shawl sign ... , inflammatory myopathy ... #Dermatomyositis ... #Diagnosis #Rheumatology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... Dermatomyositis ... heliotrope rash, Shaw sign ... , holster sign, ... Myositis #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... Polymyositis and dermatomyositis ... polyangiitis without renal ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... papules and Gottron sign ... ) • Shawl sign ... syndrome • If myopathy ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
hypofunction • Antibodies ... demyelinating disease, myelopathy ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... Sjogrens #Syndrome #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Still disease, dermatomyositis ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Antibodies targeting ... chest (in a V-sign ... shoulders (in a shawl sign ... • Clear cell renal ... diagnosis #management #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... purpura: strong sign ... C-ANCA) pattern: antibodies ... • Urinalysis (Renal ... differential #diagnosis #rheumatology
Rheumatoid Arthritis - Signs and Symptoms • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans • Pulmonary:
Rheumatoid Arthritis - Signs ... neuropathy, Cervical myelopathy ... Pericarditis • Renal ... Arthritis #RA #Signs ... Symptoms #diagnosis #rheumatology
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