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diagnosis differential erythematosus lupus systemic vasculitis ana anca antibodies antibody antineutrophil antinuclear antinxp2 antinxp2dm autoimmune classification dermatology diseases management myositis
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Dermatomyositis ... heliotrope rash, Shaw sign ... , holster sign, ... Can also see mechanics ... Myositis #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
in drug-induced SLE ... Polymyositis and dermatomyositis ... polyangiitis without renal ... ANCA+ 30-60% • Renal-limited ... antibodies #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... Abdominal pain (20%) Renal ... Thrombocytopenia #Lupus #SLE ... erythematosus #signs ... symptoms #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Still disease, dermatomyositis ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... Erythematosus #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... purpura: strong sign ... vasculitis, and SLE ... • Urinalysis (Renal ... differential #diagnosis #rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Anti-NXP-2 Dermatomyositis ... chest (in a V-sign ... shoulders (in a shawl sign ... • Clear cell renal ... diagnosis #management #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... diseases, such as SLE ... purpura: Strong sign ... Differential #Diagnosis #Rheumatology
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