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Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma: ... Pathogenesis and clinical ... Unilateral Somatic Retinoblastoma ... Bilateral Germline Retinoblastoma ... Strabismus #Retinoblastoma
Leukocoria on Ocular Examination #Leukocoria #Ocular #PhysicalExam #clinical #video #ophthalmology #retinoblastoma #pediatrics
#PhysicalExam #clinical ... ophthalmology #retinoblastoma
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 T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
Lymphocytic Leukemia Clinical ... - Positive: CD2 ... , CD3, CD8 - Loss ... of CD5 and/or CD7 ... Same morphologic/clinical
Assessing and referring childhood cancers #Diagnosis #PrimaryCare #Peds #ChildhoodCancers #ClinicalFeatures #Lymphoma #Wilms #Leukemia #Retinoblastoma #BMJ
Wilms #Leukemia #Retinoblastoma
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
- T-cell - CD7 ... , CD3 Chronic ... - B-cell CD5
Presentation of malignant disease in children Pre-school (<5 years old) - Acute lymphoblastic leukaemia
Wilm tumour - Retinoblastoma
Guide to Acute Kidney Injury (AKI) What to ask/look for: - HPI, PMH, full ROS
- Hx of AKI/CKD ... US w/ PVR - CPK ... 21% - AKI on CKD
The Cell Cycle The cell cycle is the series of tightly regulated steps that controls cell growth
Cyclin-dependent kinases (CDKs ... factor (regulators) Retinoblastoma ... Cyclin-dependent kinase #CDK ... transcription factor #Rb #Retinoblastoma
Complications of CKD - Patients with stages 1-3 ([GFR] >30 mL/min) of CKD are generally asymptomatic;
Complications of CKD ... >30 mL/min) of CKD ... derangements are not clinically ... disturbances manifest clinically ... in CKD stages 4
Selected Clinical Trials of SGLT2 inhibitors in CVD and CKD EMPA-REG OUTCOME - Empagliflozin lowered CV events
Selected Clinical ... inhibitors in CVD and CKD ... SGLT2i in HF and CKD ... SGLT2i in HF and CKD ... patients with CKD
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