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Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma: ... Pathogenesis and clinical ... Unilateral Somatic Retinoblastoma ... Bilateral Germline Retinoblastoma ... Strabismus #Retinoblastoma
Leukocoria on Ocular Examination #Leukocoria #Ocular #PhysicalExam #clinical #video #ophthalmology #retinoblastoma #pediatrics
#PhysicalExam #clinical ... ophthalmology #retinoblastoma
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 Assessing and referring childhood cancers #Diagnosis #PrimaryCare #Peds #ChildhoodCancers #ClinicalFeatures #Lymphoma #Wilms #Leukemia #Retinoblastoma #BMJ
Wilms #Leukemia #Retinoblastoma
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... double-stranded DNA ... Anti-centromere, Scl-70 (DNA ... topoisomerase I), RNA
Rifamycins - Antibiotics Class Overview Include Rifampin, Rifaximin, Rifapentine, Rifabutin. Mechanism: Inhibits bacterial DNA-dependent RNA polymerase (unique mechanism).
Inhibits bacterial DNA-dependent ... RNA polymerase
The Cell Cycle The cell cycle is the series of tightly regulated steps that controls cell growth
phase G1, G2), DNA ... gymnastics of DNA ... factor (regulators) Retinoblastoma ... senses damaged DNA ... transcription factor #Rb #Retinoblastoma
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
investigations depending on clinical ... Vasculits: ANCA, ANA ... Anti-GBM, Anti-ds-DNA ... , C3/C4, ENA, immunoglobulins
Antibiotic Classification by Mechanism of Action Cell Wall Synthesis: Penicillins Cephalosporins Carbapenems Monobactams Beta-lactamase inhibitors Glycopeptides Protein
Lincosamides DNA ... inhibitors DNA ... Recommended Text: Clinical
COVID-19 Vaccines - Comparison Chart • Moderna - mRNA-1273 mRNA in lipid nanoparticle • Pfizer -
Chimp Adenovirus-DNA ... human adenovirus/DNA ... Ad5 adenovirus/DNA
Presentation of malignant disease in children Pre-school (<5 years old) - Acute lymphoblastic leukaemia
Wilm tumour - Retinoblastoma
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