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diagnosis differential algorithm management anemia aplastic arterial bleeding bruising classification cryofibrinogenemia dermatology dyspnea embolism glomerulonephritis leukemia mds myelodysplasia myelodysplastic nonpalpable
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
inflammation • Thrombocytopenia ... : - Thrombocytopenia ... • Secondary Causes ... Differential #Diagnosis #hematology ... #rheumatology #
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... HUS • DIC • Vasculitis ... Heart Valve) #Thrombocytopenia ... Diagnosis #Algorithm #Causes ... #Hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Tamponade Pulmonary ... Vasculature: - PE - Pulmonary ... HTN - Vasculitis ... Transverse myelitis • Hematology ... #pulmonary
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Diagnosis Algorithm Thrombocytopenia ... • Steroids • Vasculitis ... Diagnosis #Algorithm #Causes ... #Hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... With associated pulmonary ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
progressing GN • New pulmonary ... glomerulonephritis and/or pulmonary ... tract, and often causes ... arthritis, obstructive pulmonary ... differential #diagnosis #rheumatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
considered in all cases ... Heparin-induced thrombocytopenia ... coagulation and other causes ... 19 - PNH - Vasculitis ... pathophysiology #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
progressing GN • New pulmonary ... MPO > PR3) • Pulmonary ... Granulomas, IgE, pulmonary ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
malignancies, vasculitis ... thrombophlebitis, pulmonary ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
infections/fevers • Thrombocytopenia ... and petechiae Causes ... Aplastic #Anemia #oncology ... #hematology #diagnosis
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