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SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
NEUROLOGIC - HEMOLYTIC ANEMIA ... (<1000/MM3) - THROMBOCYTOPENIA ... absence of hemolytic anemia ... #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
) Blood (75%): Anemia ... Leucopenia/lymphopenia, Thrombocytopenia ... symptoms #diagnosis #rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Abnormalities: macrocytic anemia ... , thrombocytopenia ... Autoinflammatory #Somatic #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Neurological 12% - Thrombocytopenia ... - Hemolytic anemia ... #differential #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
inflammation • Thrombocytopenia ... Primary Causes: - Thrombocytopenia ... - Hemolytic anemia ... Differential #Diagnosis #hematology ... #rheumatology #
Management of Immune Thrombocytopenia (ITP) . 

#Idiopathic #Thrombocytopenic #Purpura #Immune #Thrombocytopenia #ITP #Management #Hematology
Management of Immune Thrombocytopenia ... #Idiopathic #Thrombocytopenic ... Purpura #Immune #Thrombocytopenia ... ITP #Management #Hematology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
for workup of thrombocytopenia ... indicates thrombotic thrombocytopenic ... How to approach thrombocytopenia ... , Hematology 2012 ... Differential #Algorithm #Thrombocytopenia
Drug-Induced Thrombocytopenia
The diagnosis of drug-induced thrombocytopenia can be made only by demonstrating resolution of thrombocytopenia once
Drug-Induced Thrombocytopenia ... of drug-induced thrombocytopenia ... resolution of thrombocytopenia ... #Diagnosis #Hematology ... #Thrombocytopenia
Idiopathic Thrombocytopenic Purpura 
Clinical:
 • Gingival 
 • Menorrhagia 
 • GI bleeding 
 • Intracranial
Idiopathic Thrombocytopenic ... ITP #Idiopathic #Thrombocytopenic ... #Purpura #Thrombocytopenia ... Diagnosis #Overview #Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
with leukopenia, anemia ... , and thrombocytopenia ... Diagnosis #Management #Hematology ... #Rheumatology